Gunnar Boysen, PhD
Associate Professor, Department of Environmental and Occupational Health
Office: COPH 1220
2005 – Postdoctoral Fellow (Department of Environmental Sciences and Engineering), The University of North Carolina at Chapel Hill
2002 – PhD (Chemistry), Department of Chemistry University of Kaiserslautern Germany, and University of Minnesota cancer Center, Minneapolis, MN
1996 – MS (Biology), University of Kaiserslautern, and The German Cancer Research Center, Heidelberg, Germany
I am interested in understanding the interplay between chemical exposure and nutritional or lifestyle habits, such as diet selection and physical activity. To achieve this we utilize DNA and protein adducts to study carcinogen metabolism, how it is modified by nutritional components and the underlying mechanisms regulating corresponding enzyme activities. In addition studies investigate exposures related changes in common metabolic pathways, using targeted and un- targeted mass spectrometry based metabolomic approaches.
Swenberg,J.A., Fryar-Tita,E., Jeong,Y.C., Boysen,G., Starr,T., Walker,V.E., and Albertini,R.J. (2008) Biomarkers in Toxicology and Risk Assessment: Informing Critical Dose-Response Relationships. Chem Res Toxicol, 21, 253-265.
Esther,C.R., Jr., Jasin,H.M., Collins,L.B., Swenberg,J.A., and Boysen,G. (2008) A mass spectrometric method to simultaneously measure a biomarker and dilution marker in exhaled breath condensate. Rapid Commun. Mass Spectrom, 22, 701-705.
Boysen,G., Georgieva,N.I., Upton,P.B., Walker,V.E., and Swenberg,J.A. (2007) N-terminal globin adducts as biomarkers for formation of butadiene derived epoxides. Chem Biol Interact., 166, 84-92.
Boysen,G., Scarlett,C.O., Temple,B., Combs,T.P., Brooks,N.L., Borchers,C.H., and Swenberg,J.A. (2007) Identification of covalent modifications in P450 2E1 by 1,2-epoxy-3-butene in vitro. Chem Biol Interact., 166, 170-175.
Georgieva,N.I., Boysen,G., Upton,P.B., Jayaraj,K., Gold,A., and Swenberg,J.A. (2007) Quantitative analysis of N-terminal valine peptide adducts specific for 1,2-epoxy-3-butene. Chem.Biol.Interact., 166, 219-225.
Swenberg,J.A., Boysen,G., Georgieva,N., Bird,M.G., and lewis,R.J. (2007) Future directions in butadiene risk assessment and the role of cross-species internal dosimetry. Chem Biol Interact., 166, 78-83.
Albertini,R.J., Sram,R.J., Vacek,P.M., Lynch,J., Rossner,P., Nicklas,J.A., McDonald,J.D., Boysen,G., Georgieva,N., and Swenberg,J.A. (2007) Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisons. Chem.Biol.Interact., 166, 63-77.
Powell,C.L., Kosyk,O., Ross,P.K., Schoonhoven,R., Boysen,G., Swenberg,J.A., Heinloth,A.N., Boorman,G.A., Cunningham,M.L., Paules,R.S., and Rusyn,I. (2006) Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicol.Sci, 93, 213-222.
Swenberg J.A., Boysen,G., and Gorgeiva,N. (2004) The use of biomarkers to understand butadiene carcinogenesis. Toxicol.Pathol., 32, 733-735.
Boysen,G., Georgieva,N.I., Upton,P.B., Jayaraj,K., Li,Y., Walker,V.E., and Swenberg,J.A. (2004) Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene. Cancer Research, 64, 8517-8520.
Boysen,G., Kenney,P.M., Upadhyaya,P., Wang,M., and Hecht,S.S. (2003) Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. Carcinogenesis, 24, 517-525.
Boysen,G. and Hecht,S.S. (2003) Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods. Mutat.Res., 543, 17-30.