June 21, 2017

Rosalind Brigham Penney, PhD

Instructor
 

Education

MPH, Ph.D., 8/05 – 5/11 (Environmental and Occupational Health), Florida International University

Research Interest

When I decided to go back to school and study environmental health, I was very interested in pharmaceutical contamination of water supplies. As such, my research began around the study of phthalates (a form of plasticizer), and the possible role they may play in enhancing breast or brain cancers. My Master’s thesis focused on the public health assessment of di(2-ethylhexyl) phthalate contamination in children through interactions with plastic toys. My later research endeavors, and the focus of my Ph.D. dissertation, were in ER+ breast cancer resistance to tamoxifen treatment, and the role of reactive oxygen species in that resistance. Here at UAMS I am continuing research in breast cancer, though from a genetic point of view, as opposed to a proteomic one. I am currently engaged in research with Susan Kadlubar, Ph.D., and am looking forward to expanding this research in my upcoming years at UAMS.

Recent Publications:

Penney, R., Roy, D. Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer. Biochimica et Biophysica Acta. 1836(1):60-79.

Penney, R.B., Lundgreen, A., Wolff, R., Koroth-Edevana, V., Yao-Borengasser, A., Williams, S., Slattery, M., Kadlubar, S. Lack of correlation between in silico projection of function and qRT-PCR-determined gene expression levels in colon tissue. (Accepted, Pharmacogenomics and Personalized Medicine)

Penney, R., Felty, Q., and Roy, D. 2010. Erucin treatment through induction of thioredoxin reductase may alter tamoxifen resistance in LCC2 cells. Poster presentation, AACR Annual Meeting, Washington, D.C.

Penney, R., Felty, Q., Slingerland, J, and Roy, D. 2009. Modulation of thioredoxin reductase by sulforaphane may restore tamoxifen sensitivity in resistant LCC2 cells. Poster presentation, Society of Toxicology PPTOXII, Miami, FL.

Penney, R., Felty, Q., Slingerland, J, and Roy, D. 2009. Redox status contributes to tamoxifen-resistant growth of breast cancer cells. Poster presentation, AACR San Antonio Breast Cancer Symposium, San Antonio, TX.

Penney, R., Felty, Q., Slingerland, J, and Roy, D. 2008. Ebselen co-treatment counteracts the effects of antiestrogen on estrogen induced growth of breast cancer cells as well as restores the growth inhibitory effects of antiestrogen in resistant cells. Poster presentations, Department of Defense Era of Hope Conference, Baltimore, M.D..

Penney, R., Roy, D. Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer. Biochimica et Biophysica Acta. 1836(1):60-79.

Penney, R.B., Lundgreen, A., Wolff, R., Koroth-Edevana, V., Yao-Borengasser, A., Williams, S., Slattery, M., Kadlubar, S. Lack of correlation between in silico projection of function and qRT-PCR-determined gene expression levels in colon tissue. (Accepted, Pharmacogenomics and Personalized Medicine)