Read the Latest Publications by the Center Leaders

Gurley BJ, Miousse IR, Nookaew I, Ewing LE, Skinner CM, Jenjaroenpun P, Wongsurawat T, Kennon-McGill S, Avula B, Bae JY, McGill MR, Ussery D, Khan IA, Koturbash I. Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F₁ Mice. Nutrients. 2019 Apr 3;11(4). pii: E776. doi: 10.3390/nu11040776. PubMed PMID: 30987244. Read more about this study

Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules. 2019 Apr 30;24(9). pii: E1694. doi:10.3390/molecules24091694. PubMed PMID: 31052254. Read more about this study

Clemens MM, Kennon-McGill S, Apte U, James LP, Finck BN, McGill MR. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling. Food Chem Toxicol. 2019 Jan 14; 125:279-288. doi: 10.1016/j.fct.2019.01.014. [Epub ahead of print] PubMed PMID: 30654094. Read about this study

Aykin-Burns N, Pathak R, Boerma M, Kim T, Hauer-Jensen M. Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects. Semin Radiat Oncol. 2019 Jan; 29 (1):55-61. doi: 10.1016/j.semradonc.2018.10.008. Review. PubMed PMID: 30573184; PubMed Central PMCID: PMC6309800. Read about this study

Waidyanatha S, Ryan K, Roe AL, Jia W, Paine MF, Ferguson S, Gurley BJ, Welch K, Chow MSS, Devito M, Rider C. Follow that botanical: Challenges and recommendations for assessing absorption, distribution, metabolism and excretion of botanical dietary supplements. Food Chem Toxicol. 2018 Nov; 121:194-202. doi: 10.1016/j.fct.2018.08.062. Epub 2018 Aug 28. PubMed PMID: 30170118. Read about this study

Skinner CM, Miousse IR, Ewing LE, Sridharan V, Cao M, Lin H, Williams DK, Avula B, Haider S, Chittiboyina AG, Khan IA, ElSohly MA, Boerma M, Gurley BJ, Koturbash I. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 2018 Dec; 122:21-32. doi: 10.1016/j.fct.2018.09.067. Epub 2018 Sep 30. PubMed PMID:30282009; PubMed Central PMCID: PMC6219625. Read about this study

Miousse IR, Tobacyk J, Quick CM, Jamshidi-Parsian A, Skinner CM, Kore R, Melnyk SB, Kutanzi KR, Xia F, Griffin RJ, Koturbash I. Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors. Carcinogenesis. 2018 Sep 21;39(9):1117-1126. doi: 10.1093/carcin/bgy085. PubMed PMID: 29939201; PubMed Central PMCID: PMC6148987. Read about this study

McGill MR, Jaeschke H. Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation. Expert Rev Mol Diagn. 2018 Sep;18(9):797-807. doi: 10.1080/14737159.2018.1508998. Epub 2018 Aug 13. PubMed PMID: 30080986; PubMed Central PMCID: PMC6288799. Read about this study

Gurley BJ, Yates CR, Markowitz JS. “…Not Intended to Diagnose, Treat, Cure or Prevent Any Disease.” 25 Years of Botanical Dietary Supplement Research and the Lessons Learned. Clin Pharmacol Ther. 2018 Sep;104(3):470-483. doi: 10.1002/cpt.1131. Epub 2018 Jul 13. PubMed PMID: 29882958. Read about this study

McGill MR. The Problem With Predictive Values: Are We Using the Right Metrics for Preclinical Prediction of Drug Hepatotoxicity? Toxicol Sci. 2018 Sep 1;165(1):3-4. doi: 10.1093/toxsci/kfy157. PubMed PMID: 30165627. Read about this study

Gurley BJ, Tonsing-Carter A, Thomas SL, Fifer EK. Clinically Relevant Herb-Micronutrient Interactions: When Botanicals, Minerals, and Vitamins Collide. Adv Nutr. 2018 Jul 1;9(4):524S-532S. doi: 10.1093/advances/nmy029. PubMed PMID: 30032231; PubMed Central PMCID: PMC6054245. Read about this study

Bose C, Awasthi S, Sharma R, Beneš H, Hauer-Jensen M, Boerma M, Singh SP. Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model. PLoS One. 2018 Mar 8;13(3):e0193918. doi: 10.1371/journal.pone.0193918. eCollection 2018. PubMed PMID: 29518137; PubMed Central PMCID: PMC5843244. Read about this study

Lutkewitte AJ, Schweitzer GG, Kennon-McGill S, Clemens MM, James LP, Jaeschke H, Finck BN, McGill MR. Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration. Food Chem Toxicol. 2018 May;115:273-283. doi: 10.1016/j.fct.2018.03.014. Epub 2018 Mar 11. PubMed PMID: 29534981; PubMed Central PMCID: PMC5935563. Read about this study

Miousse IR, Skinner CM, Lin H, Ewing LE, Kosanke SD, Williams DK, Avula B, Khan IA, ElSohly MA, Gurley BJ, Koturbash I. Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains. Food Chem Toxicol. 2017 Nov;109(Pt 1):194-209. doi: 0.1016/j.fct.2017.08.025. Epub 2017 Aug 24. PubMed PMID: 28843594. Read about this study

Miousse IR, Murphy LA, Lin H, Schisler MR, Sun J, Chalbot MG, Sura R, Johnson K, LeBaron MJ, Kavouras IG, Schnackenberg LK, Beger RD, Rasoulpour RJ, Koturbash I. Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants. Food Chem Toxicol. 2017 Nov;109(Pt 1):690-702. doi: 10.1016/j.fct.2017.05.013. Epub 2017 May 8. PubMed PMID: 28495587; PubMed Central PMCID: PMC5656539. Read about this study

Sridharan V, Seawright JW, Antonawich FJ, Garnett M, Cao M, Singh P, Boerma M. Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model. Radiat Res. 2017 Mar;187(3):361-366. doi: 10.1667/RR14643.1. Epub 2017 Feb 23. PubMed PMID: 28231026; PubMed Central PMCID: PMC5483333. Read about this study

Lin H, Ewing LE, Koturbash I, Gurley BJ, Miousse IR. MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects. Food Chem Toxicol. 2017 Dec;110:229-239. doi: 10.1016/j.fct.2017.10.026. Epub 2017 Oct 16. Review. PubMed PMID: 29042291. Read about this study

Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes Nutr. 2017 Sep 6;12:22. doi: 10.1186/s12263-017-0576-0. eCollection 2017. PubMed PMID: 28904640; PubMed Central PMCID: PMC5588631. Read about this study

Oketch-Rabah HA, Roe AL, Gurley BJ, Griffiths JC, Giancaspro GI. The Importance of Quality Specifications in Safety Assessments of Amino Acids: The Cases of l-Tryptophan and l-Citrulline. J Nutr. 2016 Dec;146(12):2643S-2651S. Epub 2016 Nov 9. Review. PubMed PMID: 27934657. Read about this study

Pathak R, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharm Res. 2016 Sep;33(9):2117-25. doi:10.1007/s11095-016-1950-0. Epub 2016 May 23. PubMed PMID: 27216753; PubMed Central PMCID: PMC4967083. Read about this study

Liu X, Gujarathi S, Zhang X, Shao L, Boerma M, Compadre CM, Crooks PA, Hauer-Jensen M, Zhou D, Zheng G. Synthesis of (2R,8′ S,3′ E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol. Tetrahedron. 2016 Jul;72(27-28):4001-4006. Epub 2016 May 12. PubMed PMID: 27773949; PubMed Central PMCID: PMC5070675. Read about this study

Roe AL, Paine MF, Gurley BJ, Brouwer KR, Jordan S, Griffiths JC. Assessing Natural Product-Drug Interactions: An End-to-End Safety Framework. Regul Toxicol Pharmacol. 2016 Apr;76:1-6. doi: 10.1016/j.yrtph.2016.01.004. Epub 2016 Jan 9. PubMed PMID: 26776752. Read about this study

Antwi SO, Steck SE, Su LJ, Hébert JR, Zhang H, Fontham ET, Smith GJ, Bensen JT, Mohler JL, Arab L. Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans: The North Carolina-Louisiana Prostate Cancer Project (PCaP). Prostate. 2015 Sep;75(13):1419-35. doi: 10.1002/pros.23025. Epub 2015 Jun 5. PubMed PMID: 26053590; PubMed Central PMCID: PMC5072779. Read about this study

Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M. A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. Radiat Res. 2015 Mar;183(3):357-66. doi: 10.1667/RR13915.1. Epub 2015 Feb 24. PubMed PMID: 25710576; PubMed Central PMCID: PMC4688041. Read about this study

Koturbash I, Tolleson WH, Guo L, Yu D, Chen S, Hong H, Mattes W, Ning B. microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment. Biomark Med. 2015;9(11):1153-76. doi: 10.2217/bmm.15.89. Epub 2015 Oct 26. Review. PubMed PMID: 26501795; PubMed Central PMCID: PMC5712454. Read about this study

Vance TM, Azabdaftari G, Pop EA, Lee SG, Su LJ, Fontham ET, Bensen JT, Steck SE, Arab L, Mohler JL, Chen MH, Koo SI, Chun OK. Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants. Prostate Cancer. 2015;2015:728046. doi: 10.1155/2015/728046. Epub 2015 Aug 18. PubMed PMID: 26357575; PubMed Central PMCID: PMC4556330. Read about this study

Ewing LE, McGill MR, Yee EU, Quick CM, Skinner CM, Kennon-McGill S, Clemens M, Vazquez JH, McCullough SS, Williams DK, Kutanzi KR, Walker LA, ElSohly MA, James LP, Gurley BJ, Koturbash I. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules. 2019 Jun 17;24(12). pii: E2256. doi: 10.3390/molecules24122256. PubMed PMID: 31212965; PubMed Central PMCID: PMC6630875. Read more about this study