June 21, 2017

Mohammed S. Orloff, PhD

C O P H Associate Professor, Department of Epidemiology Mohammed S. Orloff, P h D
Associate Professor
 

Education

2005 –  Ph.D. in Genetic and Molecular Epidemiology/Case Western Reserve University.
1994 –  M.S. Biotechnology
1992 – B.S. Chemistry, Botany and Zoology

Research Interest

Understanding the interplay of multiple genetic and epigenetic factors in the human genome that can inform the risk for developing diseases e.g. cancers: Use of integrated ‘omics’ approach to analyze high throughput genomic data (including next generation sequencing) to understand genomic, epigenomic and non-genetic factors in disease pathways among populations of variable ethnic/genetic backgrounds. These approaches are currently being applied on breast and lung cancers in the populations of rural communities in Arkansas.

Current Research Projects

  • Screening for mutations in non-small cell lung cancer-specific candidate genes in the population of Arkansas (Seeds of Science; Mohammed Orloff, PI)
  •  Preliminary studies: applying a systematic cross-platform genomic integration to understand lung-associated diseases
  • Applying integrated omics (including analysis of next generation sequencing data) to map genes and pathways associated with Barrett esophagus and esophageal adenocarcinoma

Courses Taught

Primary area of teaching is epidemiology, genetic/molecular epidemiology and genomics. Current courses taught:

  • EPID 6101 Laboratory Methods in Epidemiology
  • EPID 5322/6322 Epidemiology II
  • EPID 5323 Epidemiology II Laboratory
  • EPID 6700 Directed Research Studies
  • EPID 6324 Genomics/Genetic Epidemiology

Recent Publications

Wanchai V, Jin J, Bircan E, Eng C, Orloff M. Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinomarisk. BMC Bioinformatics. 2019 Mar 14;20(Suppl 2):98. doi: 10.1186/s12859-019-2622-y. PubMed PMID: 30871476.

Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff M. Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process. Cancers (Basel). 2019 Apr 3;11(4). pii: E467. doi: 10.3390/cancers11040467.PubMed PMID: 30987215.

Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff M. The Association between Salt and Potential Mediators of the Gastric Precancerous Process. Cancers (Basel). 2019 Apr 15;11(4). pii: E535. doi: 10.3390/cancers11040535. PubMed PMID:30991669.

Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff MS. Using Machine Learning to Predict Progression in the Gastric Precancerous Process in a Population from a Developing Country Who Underwent a Gastroscopy for Dyspeptic Symptoms. Gastroenterol Res Pract. 2019 Apr 1;2019:8321942. doi:10.1155/2019/8321942. eCollection 2019. PubMed PMID: 31065263

Rutlen C, Orloff M, Bates J, Porter A. Crop burning and the prevalence ofasthma and COPD emergency department treatments in a rural Arkansas county. JAsthma. 2020 Jan 6:1-6. doi: 10.1080/02770903.2019.1708096. [Epub ahead of print]PubMed PMID: 31858858.

Delhey L, Shoults C, Johnson K, Orloff M, Faramawi MF, Delongchamp R. Thedifference between hypertension determined by self-report versus examination in the adult population of the USA: Continuous NHANES 1999-2016. J Public Health(Oxf). 2019 Nov 28. pii: fdz132. doi: 10.1093/pubmed/fdz132. [Epub ahead ofprint] PubMed PMID: 31781770

Apopa PL, Alley L, Penney RB, Arnaoutakis K, Steliga MA, Jeffus S, Bircan E, Gopalan B, Jin J, Patumcharoenpol P, Jenjaroenpun P, Wongsurawat T, Shah N, Boysen G, Ussery D, Nookaew I, Fagan P, Bebek G, Orloff MS. PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin. Front Microbiol. 2018 Aug 6;9:1757. doi: 10.3389/fmicb.2018.01757. eCollection 2018. PubMed PMID: 30127774; PubMed Central PMCID: PMC6087756.

Makhoul I, Todorova VK, Siegel ER, Erickson SW, Dhakal I, Raj VR, Lee JY, Orloff MS, Griffin RJ, Henry-Tillman RS, Klimberg S, Hutchins LF, Kadlubar SA. Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients. PLoS One. 2017 Jan 3;12(1):e0168550. doi: 10.1371/journal.pone.0168550. eCollection 2017. PubMed PMID: 28045923; PubMed Central PMCID: PMC5207665.

Rogers LJ, Basnakian AG, Orloff MS, Ning B, Yao-Borengasser A, Raj V, Kadlubar 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer. Nutr Metab (Lond). 2016 Aug 20;13:54. doi: 10.1186/s12986-016-0111-0. eCollection 2016. PubMed PMID: 27547236; PubMed Central PMCID: PMC4992261.

Cardenas VM, Orloff MS, Kaminaga J, Cardenas IC, Brown J, Hainline-Williams S, Duthie MS, Gonzalez-Puche AC, Mukasa L, Patil N, Mcelfish PA, Bates JH. Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA. Lepr Rev. 2016 Mar;87(1):109-12. PubMed PMID: 27255065.

Sutton J, Orloff MS, Michener C, Chiesa-Vottero A, Prayson R, Nowacki AS, Eng Association of specific PTEN/10q haplotypes with endometrial cancer phenotypes in African-American and European American women. Gynecol Oncol. 2015 Aug;138(2):434-40. doi: 10.1016/j.ygyno.2015.05.024. Epub 2015 May 28. PubMed PMID: 26026735.

Starlard-Davenport A, Orloff MS, Dhakal I, Penney RB, Kadlubar SA. Genotypic and allelic variability in CYP19A1 among populations of African and European ancestry. PLoS One. 2015 Feb 3;10(2):e0117347. doi: 10.1371/journal.pone.0117347. eCollection 2015. PubMed PMID: 25647083; PubMed Central PMCID: PMC4315570.

Orloff M, He X, Peterson C, Chen F, Chen J, Mester J and Eng C. Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. Am J Hum Genet. 2013 Jan 10;92(1):76-80

Ashida S,Orloff MS, Bebek G, ZhangL, Zheng P, Peehl DM and Eng C. Integrated Analysis Reveals Critical Genomic Regions in Prostate Tumor-Microenvironment Associated with Clinico-pathologic Phenotypes. Clin Cancer Res. 2012 Jan 24

Orloff MS,Zhang L, Bebek G, Eng C. Integrative genomics reveal extended germline homozygosity with lung cancer risk in the PLCO cohort. PLoS One. 2012;7(2)

Bebek G,Orloff M, Eng C. Microenvironmental Genomic Alterations Reveal Functional Networks for Head and Neck Squamous Cell Carcinoma. J Clin Bioinforma. 2011 Aug 2;1(1):21.

Orloff MS, Peterson, C, Ganapathi S, He X, Heald B, Yang Y, Bebek G, Romigh T,Hoon Song J, Wu W, David S, Cheng Y, Meltzer S, and Eng C. Germline Mutations in MSR1,ASCC1 and CTHRC1 in Individuals with Barrett Esophagus and/or Esophageal Adenocarcinoma JAMA. 2011;306(4):410-419.