June 20, 2017

Gunnar Boysen, PhD

Gunnar Boysen
Associate Professor
 

Education

2005, Postdoctoral Fellow, University of North Carolina at Chapel Hill, Department of Environmental Sciences and Engineering
2002, PhD, University of Kaiserslautern Germany and University of Minnesota Cancer Center, Chemistry
1996, MS, University of Kaiserslautern and The German Cancer Research Center, Biology

Research Interest

I am interested in understanding the interplay between chemical exposure and nutritional or lifestyle habits, such as diet selection and physical activity. To achieve this we utilize DNA and protein adducts to study carcinogen metabolism, how it is modified by nutritional components and the underlying mechanisms regulating corresponding enzyme activities. In addition studies investigate exposures related changes in common metabolic pathways, using targeted and un-targeted mass spectrometry based metabolomic approaches.

Courses Taught

  • Environmental Exposure Assessment (ENVH 5222)
  • Toxicology in Public Health (ENVH 5302)
  • Environmental and Occupational Health (ENVH 5102)

Recent Publications

Sappington DR, Siegel ER, Hiatt G, Desai A, Penney RB, Jamshidi-Parsian A, Griffin RJ, Boysen G. Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines. Biochimica et biophysica acta. 2016; 1860(4):836-43. NIHMSID: NIHMS758731

Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017; 378:114-124. NIHMSID: NIHMS845722

Boysen G. The Glutathione Conundrum: Stoichiometric Disconnect between Its Formation and Oxidative Stress. Chemical research in toxicology. 2017; 30(5):1113-1116.

Sappington D, Helms S, Siegel E, Penney RB, Jeffus S, Bartter T, Bartter T, Boysen G. Diagnosis of lung tumor types based on metabolomic profiles in lymph node aspirates. Cancer treatment and research communications. 2018; 14:1-6.

Barnette DA, Davis MA, Dang NL, Pidugu AS, Hughes T, Swamidass SJ, Boysen G, Miller GP. Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches. Biochemical pharmacology. 2018; 156:10-21. NIHMSID: NIHMS1502829

Link to NCIBI Bibliography