June 20, 2017

Gunnar Boysen, PhD

Associate Professor
 

Education

2005, Postdoctoral Fellow, University of North Carolina at Chapel Hill, Department of Environmental Sciences and Engineering
2002, PhD, University of Kaiserslautern Germany and University of Minnesota Cancer Center, Chemistry
1996, MS, University of Kaiserslautern and The German Cancer Research Center, Biology

Research Interest

I am interested in understanding the interplay between chemical exposure and nutritional or lifestyle habits (for instance, diet selection and physical activity) on adverse health outcome such as lung cancer. To achieve this, we apply mass spectrometry and nanopore technologies to measure DNA and protein adducts to better understand exposure and metabolism of carcinogens, how it is modified by nutritional components, and the underlying mechanisms regulating corresponding enzyme activities. In addition, we investigate exposure related changes in common metabolic pathways using targeted and un-targeted mass spectrometry based metabolomic approaches. The long-term goal of my research is to understand metabolic reprogramming of metastases to identify novel therapy targets.

Courses Taught

  • ENVH 5222 – Environmental Exposure Assessment
  • ENVH 5302 – Toxicology in Public Health
  • ENVH 5102 – Environmental and Occupational Health

Recent Publications

Schleiff MA, Payakachat S, Schleiff BM, Swamidass SJ, Boysen G, Miller PG, Impacts of diphenylamine NSAID halogenation on bioactivation risks, Toxicology 2021, Toxicology 2021, 458:152832 PMID: 34107285, DOI

Flynn NR, Ward MD, Schleiff MA, Laurin CMC, Farmer R, Conway SJ, Boysen G, Swamidass SJ, Miller GP, Bioactivation of isoxazole-containing bromodomain and extra terminal domain (BET) inhibitors. Metabolites, 2021, PMID:34203690, DOI

Boysen G, Arora R, Degner A, Vevang KR, Chao C, Rodriguez F, Walmsley S, Erber LN, Tretyakova N, and Peterson LA, Effects of GSTT1 Genotype on Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Crosslinks in Human Hapmap Cell Lines Chemical Research in Toxicology 2021, 18;34(1):119-131. PMID: 33381973, DOI

Jenjaroenpun P, Wongsurawat T, Wadley TD, Wassenaar TM, Liu J, Dai Q, Wanchai V, Akel NS, Jamshidi-Parsian A, Franco AT, Boysen G, Jennings ML, Ussery DW, He C, Nookaew I. Decoding the epitranscriptional landscape from native RNA sequences.

Nucleic Acids Res. 2021 Jan 25;49(2):e7. PMID:32710622, DOI

Nookaew I, Jenjaroenpun P, Du H, Wang P, Wu J, Wongsurawat T, Moon SH, Huang, E, Wang Y, Boysen G, Detection and discrimination of DNA adducts differing in size, regiochemistry and functional group by nanopore sequencing, Chemical Research in Toxicology 2020, 21;33(12):2944-2952,. PMID:32799528, DOI,

Pinson AO, Pouncey DL, Schleiff MA, Fantegrossi WE, Prather PL, Radominska-Pandya A, Boysen G and Grover P. Miller, Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics, Molecules Molecules 2020, 25(20), 4820; PMID:33092129, DOI

Schleiff MA, NR Flynn NR, Payakachat S, Schleiff BM, Pinson AO, Swamidass SJ, Boysen G, Miller PG, Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics, Drug Metabolism and Disposition PMID: 33239334, DOI

Trentzsch M, Nyamugenda E, Miles TK, Griffin H, Russell S, Koss B,Cooney KA, Phelan KD, Tackett AJ, Iyer S, Boysen G and Baldini G, Delivery of Phosphatidylethanolamine Blunts Stress in Hepatoma Cells Exposed to Elevated Palmitate by Targeting the Endoplasmic Reticulum, Cell Death Discov. 6, 8 (2020) PMID:30615192,DOI

Boysen G, Shimoni A, Danylesko I, Varda-Bloom N, and Nagler A, A simplified method for detection of N-terminal valine adducts in patients receiving Treosulfan. Rapid Communication in Mass Spectrometry 2019, Jun 25,33, 1635-1642, PMID:31240802, DOI

Cardenas VM, Cen R, Clemens, MM, Moody H, Uwemedimbuk SE, C A, Fischbach LA, Eswaran H, Magann, EF, Delongchamp RR, Boysen G, Use of Electronic Nicotine Delivery Systems by Pregnant Women I: Risk of Small-for-Gestational Age Birth, Journal Tobacco Induced Disease, 2019; May 17, 44, 1-12, PMID:31516487, DOI

Clemens, MM, Cardenas, VM., Fischbach LA, Cen R, Eswaran H, Siegel ER, Uwemedimbuk SE, Policherta A, Moody H, Magann, EF, Boysen G, Use of Electronic Nicotine Delivery Systems by Pregnant Women II: Hair Biomarkers for Exposures to Nicotine and Tobacco-Specific Nitrosamines, Journal Tobacco Induced Disease, 2019; Jun 17, 50, 1-9, PMID:31516493, DOI

Link to NCIBI Bibliography